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Microbiology Mechanism of Action: The inhibitory activity of acyclovir is highly selective due to its affinity for the enzyme thymidine kinase TK encoded by HSV.

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This viral enzyme converts acyclovir into acyclovir monophosphate, cheap Zovirax USA, a nucleotide analogue. The monophosphate is www.binchebeton.be converted into diphosphate by cellular guanylate kinase and into triphosphate by a number of cellular enzymes. In cell culture, acyclovir triphosphate stops replication of herpes viral DNA. This inhibition is accomplished in 3 ways: Clinical isolates of HSV with reduced susceptibility to acyclovir have been recovered from immunocompromised patients, cheap Zovirax USA with advanced HIV infection.

TK-negative mutants may cause severe disease in infants and immunocompromised adults. The possibility of viral resistance to acyclovir should be considered in patients who show poor clinical response during therapy.

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Clinical Studies Adult Subjects Zovirax Cream was evaluated in two double-blind, randomized, placebo vehicle -controlled trials for the treatment of recurrent herpes labialis. The average patient had five episodes of herpes labialis in the previous 12 months.

No significant difference was cheap Zovirax USA between subjects receiving Zovirax Cream or placebo in the prevention of progression of cold sore lesions. Pediatric Subjects An open-label, uncontrolled trial with Zovirax Cream was conducted in 113 patients aged 12 to 17 years with recurrent herpes labialis, cheap Zovirax USA. Zovirax Cream is supplied as follows: General Patients should be informed that Zovirax Cream is a prescription topical cream for the treatment of cold sores recurrent herpes labialis that occur on the face and lips. Zovirax Cream is not a cure for cheap Zovirax USA sores. Patients should be advised that Zovirax Cream should not be used in the eye, inside the mouth or nose, or on the genitals.

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